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Bandera de Perú
Bandera de Ecuador

/Sounds like "ka" (as in "karma") + "choo" (as in "achoo") + "doe" (as in the animal)/

Someone whose partner cheated on them, the Spanish equivalent of being "cuckolded." In Peru and Ecuador this is one of the most humiliating insults you can throw at someone, because it implies that everyone already knows about the cheating except the person themselves.

Example

"El pobre Juan resultó cachudo, su novia salía con su mejor amigo. -> Poor Juan turned out to be a cuckold, his girlfriend was seeing his best friend."

"No seas cachudo, revisa ese celular que vibra mucho de noche. -> Don't be naive, check that phone that keeps buzzing at night."

Word family
Regional synonyms:

Anímate, ponte de buenas, sal de ese estado de tristeza o desgano. Cuando alguien anda todo apagado o decaído, le dices aliviánate para que se sacuda la mala vibra y vuelva a funcionar como persona normal.