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/Sounds like "EER" (as in "eagle") + "seh" (as in "set") + "DEH" (as in "debt") + "MAH" (as in "mark") + "dreh" (as in "dress")/

Meaning

To spiral completely out of control, to escalate to absurd or disproportionate levels. In Spain, 'irse de madre' is when something gets taken way too far.

Examples

Prices have gone de madre, you can't even afford to live.

The party went de madre and they ended up calling the cops.

Regional synonyms
Anonymous

To fail or flunk an exam in Argentina and Uruguay. When you bombed the test so badly there's no coming back, time to call your parents with the bad news.