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/Sounds like "ah" (as in "art") + "pehn" (as in "pet") + "deh" (as in "debt") + "HAHR" (as in "hard") + "seh" (as in "set")/

Meaning

To become dumber or lose your sharpness over time, or because a situation has messed with your judgment. Used in Mexico, Colombia, and Venezuela when someone stops thinking clearly.

Examples

Desde que entró a esa empresa se apendejó mucho.

Ever since he joined that company he's lost a lot of his sharpness.

No te vayas a apendejar con ese negocio que suena muy raro.

Don't let that sketchy business deal make you lose your head.

Word family
Regional synonyms

To get angry or worked up over something, sometimes over reasons that do not quite justify the reaction. In Argentina, Chile, and Uruguay, "calentarse" describes that flash of irritation that can escalate quickly, especially over small things.