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/Sounds like "PYE" + "lahs" (as in "lava")/

Meaning

Tough luck, you're done for, or a situation that has gone irreparably wrong. In Colombia and Venezuela, "pailas" is the resigned declaration that something failed, you are out of options, or the universe is simply not on your side today. It can be said about yourself or about a situation.

Examples

He got completely screwed with that business deal.

Tough luck! I missed the bus and now I'm going to be late.

Regional synonyms
Bandera de Colombia
Macana
Bandera de Perú
Leche

Something's extremely difficult, complicated, or intense in Mexico. When a situation 'está cañón' there's no easy way out, and you'll need a ton of effort, luck, or a miracle to resolve it.